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Sosei Group

Sosei Group (4565)

Securities Code
TYO:4565
Market Capitalization
118,365 million yen

Scoreboard

Discovery Development Capital Impact Overall Quartile
3.4 4.0 4.4 3.8 4.0 1

 

Company Profile

Sosei Heptares is an international biopharmaceutical company with a strong focus on cutting-edge drug discovery using unique tech-based drug discovery platform. We aim to achieve stable revenue growth without substantial investments by concentrating our R&D resources on drug discovery, licensing drug candidates to major global pharmaceutical companies, and gaining milestone and royalty revenues (up to a mid-teen percent of net sales).

 

Core Technology

StaR®

StaR® (Stabilized Receptor) technology forms the backbone of Sosei Heptares’ integrated SBDD platform that enables us to “unlock” the potential of GPCRs through an advanced understanding of their structure. Our StaR® technology allows us to stabilize a GPCR by engineering a small number of single point mutations outside of the ligand-binding site such that they retain their organized structure even after they are removed from the cell membrane. The resulting stabilized proteins (StaR® proteins) are much more robust than the corresponding “wild-type,” or unmutated, proteins. These StaR® proteins are more readily purified and subjected to a variety of hit discovery and biophysical approaches. For example, StaR® proteins enable crystallization for detailed X-ray (or other) structure determination, which facilitates the design of innovative medicines with better safety and efficacy profiles and lower preclinical and clinical attrition rates compared to wild-type proteins. StaR® technology also enables the production of stabilized proteins that can be used for biologics discovery, either via in vitro phage screening, or for in vivo immunization.

 

Active pipeline

HTL0016878/muscarinic M4 agonist Partner Neurocrine plans to start a Ph2 trial in 2022.
Muscarinic M1 agonist Partner Neurocrine plans to start Ph1 trials in 2023.
Muscarinic M1/M4 agonist Partner Neurocrine plans to start Ph1 trials in 2023.
PF-07081532/GLP-1 agonist Current Ph1 trial by partner Pfizer will end in 2022. May advance to the next stage of development.
PF-07054894/CCR6 antagonist Current Ph1 trial at partner Pfizer will be over in 2022. May advance to the next stage of development.
PF-07258669/MC4 antagonist Current Ph1 trial at partner Pfizer will finish in 2022. May advance to the next stage of development.